Please join the Great Lakes Center, the Biology Department, and the Great Lakes ecosystem science program for the seminar "Expression and Localization of Heat Shock Protein 110 during Drosophila Development: Clues to Its Roles in Embryonic Development," presented by Douglas Easton, research professor in the Biology Department at Buffalo State, on Monday, April 17, from 4:00 to 5:15 p.m. in Bulger Communication Center East 2. All students, staff, and faculty are welcome.

Abstract
Heat shock proteins (HSPs) are a class of proteins that protect cells against environmental conditions that damage proteins. When cells undergo extreme environmental stresses, for example, heat shock, proteins can fold incorrectly or denature. Unfolded or misfolded proteins can form aggregates that interfere with cellular functions and lead to cell death. Cells respond to such stressful conditions by the synthesis of a set of heat shock proteins. Some HSPs have cognates (HSC) continually expressed in the cell. HSC and HSP molecules are identified by their molecular weights, for example, the 70 kilo Dalton heat shock protein is hsp70, and its cognate is hsc70.

Because HSPs and HSCs bind to their substrates to prevent interactions between unfolded proteins—or in order to fold, refold, or transport them—they are referred to as “molecular chaperones.” There is a complex set of molecular chaperones in all cells. These chaperones form a functionally interacting network that regulates the folding, unfolding, transport, and assembly into cellular structures and degradation of the full assemblage of cellular proteins.

Hsp110 is constitutive molecular chaperone that is not as well understood as some other hsp's. It cooperates with a number of other molecular chaperones, particularly hsp70, in the folding, transport, and degradation of cellular proteins. Since the chaperone network is so important to protein integrity and function, key chaperones may have special functions in developing embryos. We have begun to investigate the expression and localization of hsp110 in developing embryos to find clues to its developmental function.

We have investigated the regulation of hsp110 expression and the localization of hsp110 in Drosophila embryos by measuring location and quantize the expression of green florescent protein (GFP) tagged hsp110 during development. We have measured the timing and the expression of the hsp110 by quantizing the fluorescent hsp110 throughout development. Hsp110 was also shown to be inducible by heat shock. The changed cellular location of hsp110 was followed with confocal fluorescence microscopy. We have also observed differential concentration of hsp110 in embryonic structures. The above and other findings are related to the findings of other researchers. We have discovered novel correlations between our findings and those from other researchers. Further, our results lead to the conclusion that hsp110 may have multiple developmental functions in Drosophila and also protects embryos from environmental stresses that they encounter in the field.

Please join us for the professional development workshop Using Citation Managers in Your Research on Wednesday, April 12, from 2:00 to 3:00 p.m. in Butler Library 181B, the Professional Development Center. Citation managers make your research easier by organizing and managing your citations and articles. Keep track of your own research, or help students organize and cite their research for their own projects.

Please register through the Workshop Registration System.

The Anne Frank Project invites you to submit a proposal to AFP 2017: Sharing Stories/Connecting Communities, the ninth annual social justice festival, on October 3 and 4. AFP’s annual festival is an experiential exchange of ideas with a focus on processing theory into practice. We seek performances, workshops, and exhibits that actively engage participants in kinesthetic learning opportunities that

• explore the AFP 2017 theme;
• teach tools and vocabulary for community-building, conflict resolution, and identity exploration;
• embrace the life and writing of Anne Frank;
• explore a diverse array of disciplines, cultures, and viewpoints.

Proposals are due Thursday, June 15. All applicants will be contacted by early July. Please submit proposals using the AFP 2017 proposal form.

About Our Theme
Our increasingly divisive world is actually the product of a small number of powerful communities rather than the multiple diverse groups of people whose stories are often silenced by oppression, or simply unknown. AFP 2017 encourages presenters and participants to surface these marginalized communities, navigate their difficulties, address conflicts, disassemble assumptions, and practice sharing stories to connect communities and improve the world.

For more information about the proposal process and the Anne Frank Project, please visit the AFP Social Justice Festival website.

Questions? Ideas? Please contact Eve Everette, assistant director of AFP.

Please join us for a student lecture in our annual spring colloquia, "The Story of Ksenija Atanasijevi?: A Young Lady Entering Hell," presented by Milica Petrovic, philosophy and French major, on Tuesday, April 11, at 12:15 p.m. in Butler Library 242. The commentator will be Taylor Morse, philosophy major.

This will be the 100th paper presented through the department colloquia series, which started in spring 2006.

The Equity and Campus Diversity Office invites you to join us today, April 27, as we celebrate the close of another academic year with the final installment of our spring 2017 music series with the Brothers Blue, featuring Buffalo State alumnus Charlie Coughlin, during Bengal Pause (12:15–1:30 p.m.) in the Campbell Student Union.

"Rooted in the fertile tradition of old-time fiddle music, the Brothers Blue grow a sound all their own—offering a hybrid that unites fresh, original songwriting with elements of country, bluegrass, Cajun, and Irish music. They weave three-part harmonies through a rich tapestry of fiddle, banjo, and guitar."

The Equity and Campus Diversity Office invites you to join us as we celebrate the close of another academic year with the final installment of our spring 2017 music series with the Brothers Blue, featuring Buffalo State alumnus Charlie Coughlin, on Thursday, April 27, during Bengal Pause (12:15–1:30 p.m.) in the Campbell Student Union.

"Rooted in the fertile tradition of old-time fiddle music, the Brothers Blue grow a sound all their own—offering a hybrid that unites fresh, original songwriting with elements of country, bluegrass, Cajun, and Irish music. They weave three-part harmonies through a rich tapestry of fiddle, banjo, and guitar."

The final event in the Diversity Dialog Speaker Series for the spring semester, "Why Cultural Competency" (PDF, 853 KB), will be held Tuesday, April 11, from 6:00 to 7:30 p.m. in the Campbell Student Union Social Hall

This interactive dialogue session facilitated by Equity and Campus Diversity and the National Federation for Just Communities of Western New York Inc. will focus on self-analysis, social awareness, and the significance of being culturally competent in an ever-changing world. 

We hope you will join us.

From the Diversity Program Coordinator
Please join us for a screening and discussion of the documentary film The Bad Kids (2016), directed by Lou Pepe and Keith Fulton, on Thursday, April 13, at 7:00 p.m. in the Burchfield Penney Art Center.

The Bad Kids is an observational documentary that chronicles one extraordinary principal’s mission to realize the potential of students whom the system has deemed lost causes. Employing a vérité approach during a year at the school, the film follows principal Vonda Viland as she coaches three at-risk teens—a new father who can’t support his family, a young woman grappling with sexual abuse, and an angry young man from an unstable home—through the traumas and obstacles that rob them of their spirit and threaten their goal of a high school diploma.

Watch the trailer.

Visit the Facebook event page.

Download the flier (PDF, 186 KB).

All Beyond Boundaries films are free and open to the public and are followed by a discussion panel.

Come and celebrate Arbor Day and Earth Day at Buffalo State's 10th annual Environmental Information Fair on Thursday, April 20, from noon to 1:30 p.m. in the lobby of Butler Library.

Faculty, staff, and students will have many opportunities to learn more about the Maud Gordon Holmes Arboretum and several local green initiatives. The celebration will include free water and fresh fruit, plant giveaways, and a tree dedication.

This event is hosted by EVERGREEN and BSCenery.

For more information, please contact Lauren Morse, senior staff assistant in Campus Services, 878-6835.

The Burchfield Penney Art Center's new gallery guides will premiere at the center's Second Friday event, presented by M&T Bank, on Friday, April 14, from 5:30 to 7:30 p.m. Graduate students in AED 604, a museum education course, researched and created the gallery guides for visitors of all ages. Adults, teens, families, and kids may choose from a dozen unique guides to take with them in the galleries.

Gallery guides enhance visitors' experiences to investigate the exhibitions in new ways. The guides are interactive, informative, and correspond to the current exhibitions at the Burchfield Penney Art Center.

For further information, please contact Kathy Gaye Shiroki, curatorial associate, 878-3549.