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Posted: Monday, December 7, 2015

Chemistry Literature Seminar: 'Stimuli-Responsive Magnetic Nanoparticles for Targeted Drug Delivery' - December 10

Kayleigh Bemisderfer, a graduate student in forensic science at Buffalo State, will present the literature seminar "Stimuli-Responsive Magnetic Nanoparticles for Targeted Drug Delivery" at 12:30 p.m. Thursday, December 10, in Classroom Building B119. Light refreshments will be served before the seminar. This seminar is supported by the Faculty-Student Association. The abstract of her talk appears as below.

Abstract
Magnetic nanoparticles are being used for various biomedical applications in which they facilitate laboratory diagnostics and therapeutics. The good biocompatibility and superparamagnetic nature of these molecules make them specifically useful for drug delivery purposes. Many different drug carriers have been developed for transporting anticancer drugs specifically to tumors in order to improve treatment efficacy while preventing undesired side effects. Among these, magnetic iron oxide (Fe3O4) nanoparticles have attracted much interest in drug delivery applications because they can be suitably modified to carry drug molecules and be magnetically guided to the targeted organs or tumor sites inside the body. This allows for the prevention of damage to normal tissues due to drug toxicity even before reaching the targeted location, thereby improving the therapeutic effect. Recently, many studies have been focused on the fabrication of stimuli-responsive core-shell magnetic polymer composites.

Synthesis of a magnetic and pH-responsive nanocarrier with a multilayer core-shell structure was reported. Preparation was based on silica-coated magnetite nanoparticles successively coated with poly(benzyl L-aspartate) (PBLA) and poly(ethylene glycol) (PEG). The Fe3O4@SiO2 nanoparticle functions as a superparamagnetic core used to direct the drug loaded nanocarrier to the targeted site via an external magnetic field. The PEG chains are connected to the surface via pH-sensitive benzoic-imine bonds, serving as a pH-sheddable hydrophilic corona, while the PBLA segments serve as a hydrophobic middle layer used to load the anticancer drug (DOX) via hydrophobic interactions. Meanwhile, synthesis of temperature and pH-responsive core-shell nanoparticles was also reported. Theses nanocarriers were composed of dual responsive poly(N-isopropylacrylamide)-block-poly(acrylic acid) copolymer coated on superparamagnetic magnetite core, tethered with folic acid to improve cancer cell specific targeting. The resultant nanocomposites could serve as a versatile biocompatible vehicle for selective loading, targeted delivery, and pH-responsive release of anticancer drug Doxorubicin (DOX).

Submitted by: Jinseok Heo
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