The Daily Bulletin Archive

Please join the Chemistry Department for the next online seminar of the fall 2023 seminar series, "Exploring Crystallization Processes in Amorphous Pharmaceuticals," presented by Sarah E Wolf, assistant professor of chemistry at SUNY Cortland, today, November 9, at 12:30 p.m.

Microsoft Teams meeting
Meeting ID: 280 270 309 869
Passcode: wVzxzd
Download Teams | Join on the web

Abstract
Amorphous solids, or glasses, play an important role in many industries. In the pharmaceutical industry, drugs may be preferentially used in the amorphous state due to higher solubility, and therefore higher bio-availability. Alternatively, drugs may exist as amorphous as a consequence of preparation processes common in the industry, including grinding or spray-drying. In either case, understanding and maintaining the properties of amorphous drugs demands that they remain in the glassy state; however, as it is a more thermodynamically favorable state, there is a tendency toward crystallization. Extensive work has investigated the processes involved in this crystallization and potential tools to slow or effectively stop the process. This work aims to further this work by considering the effect of preparation conditions and, in particular, consider how confinement effects can be exploited to slow or prevent the nucleation of crystals in amorphous materials.